New Hope for Stroke Recovery

By smallory, 04/05/2017


While more people are surviving strokes, many still face long-term disability. But Johns Hopkins research finds promising ways to retrain the brain and regain independence. Here’s what experts have learned about the power of physical rehab.

 

The good news about stroke: More people are surviving the initial stroke. The bad news about stroke: More people are surviving the initial stroke with disabilities which might have been minimized if they had received the kind of early, intensive physical rehabilitation that researchers find can improve function and reduce long-term disability. In fact, as many as 60 percent are left with diminished use of an arm or leg.

“When we speak about recovery we’re really talking about how the nervous system adapts to the brain missing a part of functioning tissue,” explains Johns Hopkins expert Steven Zeiler, M.D., Ph.D. “We’ve done all we could in the acute period, but the damage is done and it’s irreversible.” The question then becomes, “How do you get the remainder of the nervous system to adapt?” In other words, can we get other parts of the brain to pick up the slack? Turns out that yes, we can.

Retraining the Brain

A groundbreaking Johns Hopkins study from Zeiler and his colleagues confirmed what clinicians have long suspected—we can rewire the brain so that one part takes over functions typically handled by another, now damaged, area.


In studies conducted with mice, the researchers first taught the mice a special way to reach for food. The task is typically directed by a part of the brain called the primary motor cortex, which is involved in physical coordination. Then they gave the mice mild strokes that damaged this motor cortex. As expected, the mice could no longer perform the reaching task with their pre-stroke level of precision. Two days after the stroke, however, researchers began retraining the mice and, after a week, the mice performed the task just as well as before the stroke.

The damaged part of the brain hadn’t recovered, says Zeiler. Instead, another part of the brain called the medial premotor cortex took over. To show that, researchers gave the mice strokes in that part of the brain and saw the reaching ability again disappear. But, once again, the mice relearned the task as yet another part of the brain stepped in to handle the job of the medial premotor cortex.

In a similar study, the researchers found that the earlier retraining started, the better. “If you retrained the mice after a one-day delay they got better, but after a seven-day delay they didn’t improve,” Zeiler says.

Johns Hopkins’ Kata Project, a collaboration between neuroscientists, engineers, animal experts, artists and entertainment industry experts, has designed an immersive experience for post-stroke patients who will try to “swim” as a virtual dolphin named Bandit. Upcoming clinical trials will determine if this unique experience helps patients recover motor function faster than the current conventional treatment of repetitive exercises.

 

Source: http://www.hopkinsmedicine.org/health/healthy_aging/healthy_body/new-hope-for-stroke-recovery

 
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Comments

That's good news! Very interesting indeed. I still believe that a diligent exercise program enables your body to recover disabilities also. :cool:

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I have been reading a lot about neuro plasticity , that the brain is able to train other parts of the brain to do what the damaged part can no longer do, but it takes hours and hours of retraining, repetitive exercises, constraint induced therapy involves this as does the saebo flex, 

  problem is it takes so long to see improvement that it is easy to give up, I have of late decided to put my best effort into using my left hand as much as possible and occasionally I see a glimmer of more movement trying to grasp, so frustrating, but you have to keep on trying for sure and hope that it will get easier. :2thumbs: 

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I also am not able to log on to stroke net not sure am i using the wrong address, please let me know what tried to add a comment to something else and I don't think it worked. NEED HELP:huh:

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You must have read "Stronger after Stroke". I read that and it motivated me to do more exercises daily, some 3 times a day. After just 2 months, I'm seeing improvements. Great book!

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This is really interesting, and well thought out.  The statement "In a similar study, the researchers found that the earlier retraining started, the better. “If you retrained the mice after a one-day delay they got better, but after a seven-day delay they didn’t improve,” Zeiler says" indicates they are quite advanced in preparation for the clinical trials.  The outcome will be awaited by many neurologists!

Can only hope they come up with a speedy retraining for the survivors who have cognitive impairments.  :blushing: 

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Whilst accepting that early attempts to recover loss of movement in arms, legs and voice have the best effect. I can assure people that from my own experience I am still with exercise managing to improve my fingers, arm and leg use after two and a half years. Incredibly slowly, but still improving.

I am getting rather annoyed with my lack of progress with my voice but other people say I am talking better, They may be just being kind!

Deigh

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