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Exosomes delivering drugs to the brain



This might make it easier to deliver a lot of the drugs I mentioned in my main blog.




A new way of delivering drugs to the brain has been developed by scientists at the University of Oxford.


They used the body's own transporters - exosomes - to deliver drugs in an experiment on mice.


The authors say the study, in Nature Biotechnology, could be vital for treating diseases such as Alzheimer's, Parkinson's and Muscular Dystrophy.


The Alzheimer's Society said the study was "exciting" and could lead to more effective treatments.


Research barrier


One of the medical challenges with diseases of the brain is getting any treatment to cross the blood-brain barrier.


The barrier exists to protect the brain, preventing bacteria from crossing over from the blood, while letting oxygen through.


However, this has also produced problems for medicine, as drugs can also be blocked.


So would this help get

tPA in;





nitric oxide;


tgf alpha;

lobster shells;




drug that activated the sigma-1 receptor;

Docosahexaenoic acid (DHA), a component of fish oil?


All these possibilities just waiting to be further tested. Ask your doctor which ones s/he believes has the most promise and when they are going to start a clinical trial. Come on lets start the guilt trips on our medical staff.

I know this is presuming a lot in suggesting survivors might actually have ideas for researchers. I am planning on putting this in a letter to the director of NINDS, Ms. Brown


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Dean: very exciting! As you know, the biggest drawback to the Baclofen pump, for Bruce, is the surgery. There are always risks, especially when one is messing with the spinal cord. And then, of course, another lifelong project to maintain it.


This kind of progress, like stem cells, comes with its own set of negatives, of course. But from all of our viewpoints, a huge step. Thank you, Debbie

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